2D depictions - Get a depiction of a SMILES string and if possible insert the depiction into the current document (such as when writing an email in GMail). Command name is "depict"

SMILES from Synonyms - Get the SMILES representation for a compound synonym. Uses the PubChem mirror at IU. Command name is "syn2smiles"

Toxicity estmation - Determine whether a compound is toxic or not using the ToxTree web service hosted at IU. It's not always accurate since the name to structure service does not always get what you expect (e.g., water is regarded as poisonous!). Command name is "toxic"

Simple format convertion - Convert a SMILES string to InChI, InChI key or SDF. The command is "reformat" and example usage would be 'reformat CCC to inchi' or 'reformat CCC to sdf' or 'reformat CCC to inchikey'. If applying to a text selection, the command would be 'reformat this to inchi'

MeSH term count - Get a count of occurence of MeSH headings over a set of PubMed ID's. Inspired by this post. You can also access a REST service here. PubMed ID's need to be given as a comma seperated list: 'meshfreq 123,345'